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By contrast, a porcine enzyme entitled SscGST A2-2, linked to ovarian follicular differentiation and showing 84% sequence identity with the human enzyme, was found to approach the high ketosteroid activity of HsaGST A3-3 ( Based on mutational studies of human GSTs the five H-site residues in positions 10, 12, 111, 208, and 216 were judged to be of particular importance for the ketosteroid isomerase activity (Pettersson et al., 2002)

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The role of nuclear factor kappa B (NF-B) in development and treatment of COVID-19: review